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KMID : 0386520100190010049
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Research Institute of Korean Medicone
2010 Volume.19 No. 1 p.49 ~ p.54
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Effects of aqueous extracts from Lonicera japonica and Tussilago farfara on RAW 264.7 Macrophages
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Lee Eung-Seok
Yang Su-Young
Park Yang-Chun
Oh Young-Seon
Lee Jin-Woo
Lee Yong-Koo
Oh Young-Seon
Cho Jung-Hyo
Kang Wee-Chang
Hong Kwon-Eui
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Abstract
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Inhalational drug is an attractive modality for local therapy of pulmonary diseases as well as systemic drug delivery. Flower of Lonicera japonica (FLJ) and flower of Tussilag farfara (FTF) are medicinal herbs for respiratory disease in traditional Korean medicine. As a preliminary study for effective inhalable formulation of FLJ and FTF, this study was to provide the toxicity and anti-inflammatory effect on murine macrophages. The dried FLJ and FTF were extracted with distilled water, filtered and freeze-dried. After treatment with FLJ and FTF extract on RAW 264.7 cells, the cell viabilities were measured by MTT assay. FLJ and FTF did not show cytotoxicity on RAW 264.7 cells. LPS stimulated RAW 264.7 cells were treated with 3 and of FLJ or FTF. FLJ and FTF did not inhibit TNF-a and IL-6 secretion in both concentration of treatment. We suggest that FLJ and FTF may be useful drugs for respiratory disease. Future work will focus on the physical characteristics for inhalable formulation.
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KEYWORD
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